By doing so, MLN4924 inhibits the entire neddylation pathway and blocks the activation of CRLs, thus inducing the accumulation of various tumor-suppressive CRL substrates which trigger cell-cycle arrest, DNA damage, apoptosis or senescence (Zhou et al., 2018; Liang et al., 2020; Zhou and Jia, 2020). This evidence concerns the gene IL31RA and neoplasm.