Currently, macrophages are targets in some cancer therapy, including: (1) Depletion macrophages via targeting colony-stimulating factor 1 (CSF1) and colony-stimulating factor 1 receptor (CSF1R) pathway, such as with the small molecule PLX3397 (Butowski et al., 2016; Yan et al., 2017). This evidence concerns the gene CSF1 and cancer.