NEDD8 and cancer: Recent studies from our and other groups demonstrate that protein neddylation (NEDD8 and NEDD8-conjugated proteins) and the key components of the neddylation pathway (NAE, UBE2F, UBE2M, RBX1, RBX2) are overactivated in multiple human cancers (Li et al., 2014; Hua et al., 2015; Xie et al., 2017; Zhou et al., 2017; Yu et al., 2018; Tian et al., 2019; Jiang et al., 2020; Wang et al., 2020).