TGFB1 and neoplasm: Breg cells support carcinogenesis, tumor progression and metastasis predominantly, although not exclusively, through the production of IL-10, TGF-β, and IL-35 or by intercellular contact (Ammirante et al., 2010; Shao et al., 2014; Tao et al., 2015; Wang et al., 2015; Schwartz et al., 2016; Xiao et al., 2016; Sarvaria et al., 2017).