BCAT1 and cancer: In addition, the bioinformatics analysis, including gene expression profiling as well as the associated GO and KEGG analyses and GSEA, showed that BCAT1 might affect invasion- and proliferation-related pathways, including ECM–receptor interaction, cytokine–cytokine receptor interaction, focal adhesion, and the PI3K–Akt signaling pathway, which all have critical roles in mediating survival signals in cancer (Martini et al., 2014; Bao et al., 2019).