A further study reveals that both PPARγ and GREM1 are the direct target genes of miR-27a, and upregulation of miR-27a impairs adipogenesis and enhanced osteogenesis in steroid-induced rat BMSCs, suggesting that miR-27a is a potential target for the treatment of steroid-induced osteonecrosis of the femoral head (Gu et al., 2016). This evidence concerns the gene PPARG and osteonecrosis.