Interleukin-1β (IL-1β), as one of the most common proinflammatory cytokines, suppresses the synthesis of proteoglycan and collagen and increases significantly in chondrocytes and synoviocytes of osteoarthritis patients, suggesting that IL-1β plays a crucial role in osteoarthritis development (Wang et al., 1997; Kapoor et al., 2011). Here, IL1B is linked to osteoarthritis.