To enhance the delivery of LDE225 at the tumor site, the NPs have been designed for a “dual targeting” mediated by: i) the recognition of CD15 ligand expressed on murine SHH-MB cancer stem-like cells by the anti-CD15 antibody present on the surface of NPs; ii) the receptor-mediated transcytosis following the direct interaction of ApoA1 to SR-B1, expressed either on brain endothelial cells or SHH-MB cells (Kim et al., 2020). This evidence concerns the gene FUT4 and neoplasm.