Similar enrichment groups related to inflammation as seen in both transcriptional studies performed to date on LS skin were reflected; however, the specific genetic profile of the pediatric LS samples more closely matches the samples within the inflammatory signature that were analyzed with the SSc samples described by Milano et al. Furthermore, within the diverse group of samples included in this study, a distinct subset of patients expressed similar inflammatory genes including interferon-inducible chemokines such as CXCL9, CXCL10, CXCL11, and IFNγ itself. This evidence concerns the gene IFNG and systemic sclerosis.