Among 11 FDA-approved PD-L1 linked companion diagnostic tests for seven tumor types (https://www.fda.gov/medical-devices/vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-vitro-and-imaging-tools), six tests for six tumor types used the PD-L1 IHC 22C3 pharmDx assay, six tests for five tumor types used tumor cells and immune cells for PD-L1 staining, and five tests for five tumor types used Combined Positive Score (CPS) as the scoring system. This evidence concerns the gene CD274 and neoplasm.