POLE and neoplasm: 4) Other high impact genes, such as TGFB1 with a known role in promoting tumor immune escape and ICI resistance (107–109), SOX10 with known function in promoting T cell-mediated tumor cell attacking (110, 111), SERPINB9 with a demonstrated role in regulating ICI resistance, and POLE/POLD1 with an established role in contributing to high TMB in some cancers (54).