GSEA using the c2 reference gene set suggested that LGG patients with high-risk score phenotypes are significantly different from low-risk score phenotypes in the following pathways: CD8/TCR pathway, natural killer cell mediated cytotoxicity, B cell receptor signaling pathway, PI3KCI pathway, caspase pathway, TH1/TH2 pathway, P53 pathway, metastasis up, tumor vasculature up, JAK/STAT signaling pathway, cell adhesion molecules CAMs, P38/MAPK pathway, Wnt pathway require Myc, signaling by Rho gtpases, tumorigenesis up and NF-κB pathway (Figures S2A–P). The gene discussed is TP53; the disease is neoplasm.