CD8A and neoplasm: CD8+ T cells may release granzymes during granule exocytosis when tumor cells are marked for elimination12,13,76, and the granzymes may induce caspase-independent apoptotic pathways77,78 which support the presence of hollow cavities in the tumor areas with low caspase-3 expression55 as seen in the IT group (Figure 5f andFigure 6d).