Similarly, CD4+ and CD8+ T cells were also found around the proliferating tumor cells that may respond to certain antigens in the mammary tumor cells, within blood vessels, and in the necrotic areas12,13, which were characterized by inflammation33,34 (Figures 7c and 7d for CD8,Figures 7e and 7f for CD4). This evidence concerns the gene CD4 and neoplasm.