Besides, SP1 reduces Aβ40 induced cytotoxicity, oxidative stress-mediated apoptotic events, and dysregulation of Ca2+ homeostasis in human neuroblastoma SH-SY5Y cells.29,30SP1 also improves Aβ40 induced ROS generation and modulates apoptosis signalling in the cells. Here, SP1 is linked to neuroblastoma.