BCL2 and neoplasm: It is known that intrinsic apoptosis is regulated by the Bcl-2 protein family which includes pro-survival and proapoptotic subgroups.5 Bcl-2 pro-survival protein has been implicated in tumor survival and drug resistance, and its overexpression is positively correlated with resistance of many malignancies, including melanoma.6 These findings suggest that Bcl-2 pro-survival protein is involved in the resistance of B16F10 to CTN.