A family of enzymes that have received significant attention are the cytochrome P450 (CYP) enzymes.54,55 In 2019, Ma et al. described a probe to determine the catalytic activity of CYP450, and in particular the isoform CYP2J2, a potential cancer biomarker involved in cell proliferation, angiogenesis, and metastasis.56,57 Like CYP1A, CYP2J2 effects o-dealkylation of its substrates. Here, CYP2J2 is linked to cancer.