AKT1 and cancer: For MF analysis, the most significant result was protein binding, and, at the same time, predicted genes were enriched in ATP binding, protein serine/threonine kinase activity (Figure 4D), etc. The predicted target genes of miR-497 were mainly concentrated in PI3K/Akt signal pathway, proteoglycan in cancer and p53 signal pathway (Figure 4E), etc.