In the research of Yang et al., a high level of intracellular miR-1246 reduced the GSK-3β level, followed by the activation of the Wnt/β-catenin pathway, accounting for the initiation and enhancement of Epithelial-Mesenchymal Transition (EMT), which finally led to the metastasis of lung cancer cells (Wu and Yan, 2020). The gene discussed is GSK3B; the disease is lung carcinoma.