Interestingly, it was confirmed that fourteen genes (ARL2, HSPG2, UBE2Q1, PHF19, CPD, APLN, CHEK1, CASK, SUCO, PPP1R11, CCNE1, KIF23, TMEM183A, and FASN) in miR-497 are highly expressed in hepatocellular carcinoma. Here, APLN is linked to hepatocellular carcinoma.