We ranked candidate genes in descending order according to their degree in the gene-hallmark network and found that 60% of the top 20 genes were known cancer genes including EGFR, MYC, HRAS, PTK2, CCND2, PDGFRA, CDKN2B, PTPN6, CDKN2A, DTX3, HAS2, and CDK4 (Figure 2B). This evidence concerns the gene PTPN6 and cancer.