CDK4 and cancer: We ranked candidate genes in descending order according to their degree in the gene-hallmark network and found that 60% of the top 20 genes were known cancer genes including EGFR, MYC, HRAS, PTK2, CCND2, PDGFRA, CDKN2B, PTPN6, CDKN2A, DTX3, HAS2, and CDK4 (Figure 2B).