EGFR and cancer: We found that EGFR amplification significantly affected many cancer hallmarks, including development signature (EPITHELIAL_MESENCHYMAL_TRANSITION, P = 0.012), immune signature (ALLOGRAFT_REJECTION, P = 0.004; IL6_JAK_STAT3_SIGNALING, P = 0.005; INTERFERON_ GAMMA_ RESPONSE, P = 0.013) (Supplementary Figure 2A).