A microRNA, MiR-542-3p, is downregulated in human CRC cancers and introducing this microRNA into HCT116 and SW620 CRC cells changes the morphology of the cells and reduces cell adhesion, as well as suppressing invasion via downregulation of the ILK/FAK/c-Src pathway (Oneyama et al., 2012). The gene discussed is PTK2; the disease is colorectal carcinoma.