AKT1 and malignant colon neoplasm: For example, Cryptotanshinone, which is derived from Salvia miltiorrhiza Bunge, suppresses CT26 colon cancer cell angiogenesis via inhibiting the PI3K/Akt/mTOR signaling pathway, nuclear hypoxia inducible factor-1α (HIF-1α), VEGF and VEGFR gene activation (Zhang et al., 2018).