It has been reported that NF-κB p65 is activated in senescent cells and is considered as a master control of SASP in CRC as well as in many cancers (Chien et al., 2011; Pazolli et al., 2012; Bernal et al., 2014; Strzeszewska et al., 2018). The gene discussed is NFKB1; the disease is cancer.