PDPN and neoplasm: Upregulation of podoplanin is observed on inflammatory mouse macrophage cell line, RAW264.7, primary macrophages such as bone marrow-derived macrophages (BMDM), peritoneal macrophage following peritonitis, tumour-associated macrophages and monocyte-derived macrophages in the inflamed lung, liver, skin and other organs (3, 10, 12, 20, 28, 30–32).