Increased expression of cytokines/chemokines, and several clinical abnormalities reflecting hyperinflammation and tissue damage in CS disorders (22), (e.g., increased levels of C-reactive protein and lactate dehydrogenase, hypoalbuminemia, thrombocytopenia, hepatic and renal insufficiency) were also observed in HAdV-infected patients (Table 1), indicating that the CS occurred following HAdV infection. The gene discussed is CRP; the disease is Cowden syndrome 1.