TNF and Sepsis: H3K27me3, the repressive epigenetic mark induced by EZH2, persists to inhibit IL12 immunity at least 6 weeks after the initial septic insult (155).EZH2 expression increases proportional to disease severity and correlates with poor clinical outcomes in sepsis (156).In multiple cancers EZH2 induced epigenetic mark inhibit IFN-γ-JAK-STAT signaling (157–160).In TB, EZH2 is expressed early (161), with EZH2 inhibition decreasing Ifng and Tnf H3K27me2 and increasing TNF and IFN-γ production (162).