The differential KEGG enrichment pathways in the PE group mainly consisted of circadian entrainment, renin secretion, vascular smooth muscle contraction, aldosterone synthesis and secretion, pantothenate and CoA biosynthesis, biotin metabolism, renin-angiotensin system, gap junction, serotonergic synapse and acute myeloid leukemia (Figures 5C, D). This evidence concerns the gene REN and acute myeloid leukemia.