↑CD68 marker in obesity and in T2DM.↓CD11b, CD11c, CD163 and CD169 in T2DM patients↑TNFα, iNOS, IL-6, CD16, CD36, and CD206 in the T2DM Metformin restored TNFα, iNOS, IL-6, CD11c, CD36, CD169 and CD206 in T2DM patients to levels equivalent to those of lean volunteers. The gene discussed is NOS2; the disease is type 2 diabetes mellitus.