↑CD68 marker in obesity and in T2DM.↓CD11b, CD11c, CD163 and CD169 in T2DM patients↑TNFα, iNOS, IL-6, CD16, CD36, and CD206 in the T2DM Metformin restored TNFα, iNOS, IL-6, CD11c, CD36, CD169 and CD206 in T2DM patients to levels equivalent to those of lean volunteers. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.