In addition, we showed conclusively that the frequency of HLA-B*01:01:01:01 was over represented in Italian and Norwegian AChR-EOMG patients compared to controls; in fact HLA-B*08:01:01:02 occurs at much lower frequencies (AF ~0.005, n = 1 or 2) in the Italian group regardless of disease status, and was not observed at all in Norwegians. The gene discussed is HLA-B; the disease is atrial fibrillation.