CX3CR1 and liver dysplastic nodule: Such findings related to mesangial cells in DN are consistent with reports in an acute glomerulonephritis model, indicating that CX3CL1, produced by mesangial cells plays a role in monocyte recruitment to the kidney (45) and in in vitro culture systems demonstrating that murine monocytes adhere to mesangial cells in a CX3CL1-CX3CR1 dependent fashion (46).