In this regard, rotavirus is recognized in the intestinal mucosa by germ-line-encoded pattern-recognition receptors (PRRs) including Toll-like receptor (TLR)-3, retinoic acid-inducible gene-I (RIG-I), and melanoma differentiation-associated gene-5 (MDA-5), stimulating cellular signaling cascades that culminate in the expression of type I interferons (IFNs), antiviral factors and inflammatory cytokines and chemokines that orchestrate the local innate immune response to react to viral infection (9, 10). This evidence concerns the gene RIGI and viral infectious disease.