IFIH1 and viral infectious disease: In this regard, rotavirus is recognized in the intestinal mucosa by germ-line-encoded pattern-recognition receptors (PRRs) including Toll-like receptor (TLR)-3, retinoic acid-inducible gene-I (RIG-I), and melanoma differentiation-associated gene-5 (MDA-5), stimulating cellular signaling cascades that culminate in the expression of type I interferons (IFNs), antiviral factors and inflammatory cytokines and chemokines that orchestrate the local innate immune response to react to viral infection (9, 10).