IL10 and colitis: Since 1,25(OH)2D induces expression of FOXP3 and IL-10, while RA stimulates expression of gut-homing receptors in T cells, the approach led to the induction of Treg cells in vivo, in peripheral lymphoid tissues, and subsequent homing of Treg cells in the intestine followed by stable suppression of intestinal inflammation in a mouse model of colitis (419) (Figure 5).