Many pediatric CNS tumors express B7-H3; in particular, high B7-H3 expression has been found in the following tumors: atypical teratoid/rhabdoid tumors (ATRT), ependymomas (all grades), MB, CNS embryonal tumors, choroid plexus tumors (CPTs), meningioma and craniopharyngiomas (136, 137). This evidence concerns the gene CD276 and central nervous system neoplasm.