Of note, our data indicate that B cells lack a sustained negative feedback mechanism of MyD88s induction to rescue mutated cells from MyD88-driven oncogenesis: For example, TLR stimulation induced MyD88s in TLR-stimulated hMoMacs and B cells at short time points, but MyD88s was not prominently expressed or regulated under the extended presence of NF-κB stimuli in B cells and lymphoma cell lines. Here, MYD88 is linked to lymphoma.