Infection with site mutants (such as ROKA63-ACCI and ROKA63-5M) impaired the interaction of IE-63 and ASF1, and infection with a mutant with complete deletion of the IE-63 gene (ROKA63D) led to impaired establishment of VZV latency in rodents (Cohen et al., 2004, 2005). This evidence concerns the gene SRSF1 and infection.