A recent study on the mechanism of thrombocytopenia in SLC35A1-CDG (OMIM#603585) proposed that sialylation is the major capping glycan structure on megakaryocytes and platelet membrane glycoproteins; in mice with sialylation defects, impaired megakaryocyte maturation and excessive platelet clearance in the liver were found (35). The gene discussed is SLC35A1; the disease is Thrombocytopenia.