In brief, the PD-L1-AuNPs-DOX model (Figure 2) successfully facilitated the efficient intracellular uptake of DOX and NIR irradiation obviously and synergistically suppressed the in vitro proliferation of CRC cells by increasing apoptosis and cell cycle arrest, and this model in combination with synergistic targeted chemo-photothermal therapy has potential for the treatment of localized CRC. This evidence concerns the gene CD274 and colorectal carcinoma.