CD8A and neoplasm: Huang et al. (2020) focused on a model, named targeting polymer and folic acid-modified gold nanoparticles (AuNPP-FA), which can both restrain tumor angiogenesis and promote vascular normalization. It is because of the increased infiltration of CD3+CD8+ T lymphocytes that the immunotherapeutic response was enhanced by decreasing vascular permeability and improving vascular perfusion.