SQSTM1 and metabolic dysfunction-associated steatotic liver disease: Interestingly, NAR decreased the expression of p62 in NAFLD rat livers at 30 and 90 mg/kg, decreased LC3-II/LC3-I at 30 mg/kg but increased it at 90 mg/kg (Figures 7A–C). NAR increased the expression of p62 in 3T3-L1 adipocytes (Figures 7D,E ) and C2C12 myotubes (Figures 7G,H).