ACE and hydrops fetalis: Based on these results, we suggested that the dominance of ACE-2/Ang-(1–7) over ACE/Ang II in the adaptive stage of HF may contribute to the late onset of apparent cardiac dysfunction in this model and the balance between ACE/Ang II and ACE-2/Ang-(1–7) in favor of the first axis determines the progression to the end-stage of HF.