Indeed, corticosteroids have been shown to suppress CRS (Lee et al., 2014), and NR3C1 has been shown to transcriptionally downregulate many inflammatory cytokines overexpressed in COVID-19 patients, such as CCL2, IL1B, and IL6 (Kadiyala et al., 2016; Sasse et al., 2016). The gene discussed is NR3C1; the disease is congenital rubella syndrome.