Similar to NF-κB TFs, AP-1 TFs (FOS and JUN) are critical regulators of inflammatory cytokine genes such as CCL2 and IL6 (Akira et al., 1993; Martin et al., 1997), which are expressed at high levels in COVID-19 patients (Blanco-Melo et al., 2020; Huang et al., 2020; Merad and Martin, 2020). The gene discussed is FOS; the disease is COVID-19.