CTNNA2 is a tumor suppressor gene frequently mutated in laryngeal cancer, and CTNNA2 and CTNNA3 mutations increase the migration and invasion capabilities of head and neck squamous cell carcinoma cells (Fanjul-Fernandez et al., 2013; Wang et al., 2014; Rizzato et al., 2016). Here, CTNNA2 is linked to head and neck squamous cell carcinoma.