Besides, PET imaging has been established as a standard approach to investigate pathological features and imaging biomarkers for AD, including neuritic plaques of amyloid-β peptide fibrils (Nordberg, 2004), hyper-phosphorylated tau neurofibrillary tangles (Ossenkoppele et al., 2016), as well as their respective propagation patterns (Sepulcre et al., 2018; Guo et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.