MGMT and neoplasm: Of the 357 patients, 40 (11%) were over 65, 230 (64%) were male, 208 (58%) had wild-type IDH, 196 (55%) had a longest diameter over 5 cm, 237 (66%) had tumor-ependymal region contact (ependymal +), 120 (34%) had tumors separated from the ependymal region (ependymal-), 53 (15%) had MGMT expression over one plus, 226 (63%) had EGFR expression over one plus, 158 (44%) had VEGF expression over one plus, and 141 (39%) had Ki67 expression over 40% (Table 1).