Additionally, the p38MAPK and ERK pathways are involved in the regulation of the pathophysiological functions of various related diseases mediated by TRPV1 (Shin et al., 2016; Hong et al., 2017) and the pathogenesis of inflammatory and neurodegenerative diseases mediated by the P2X7 receptor (Ji et al., 2018; Yu et al., 2018; Pérez de Lara et al., 2019). The gene discussed is TRPV1; the disease is neurodegenerative disease.