MAPK3 and migraine disorder: Recent studies showed that 5-HT7R could influence PKA- or ERK1/2-mediated signaling pathways, which mediate sensitization of nociceptive neurons via interacting with Gαs-cAMP (Ohta et al., 2006; Cho et al., 2015), Previous studies found that blockade of 5-HT7R mediated craniovascular vasodilatation and perivascular trigeminal nerve endings in migraine rats.