Recent evidence suggests that TSPAN8 has an important role in tumor invasion and metastasis in multiple types of tumors, including PDAC [10], ovarian carcinoma [11], gastric adenocarcinoma [12], colon adenocarcinoma [13], liver hepatocellular carcinoma [14], esophageal carcinoma [15], melanoma and glioma [16]. The gene discussed is TSPAN8; the disease is neoplasm.