Taken in the context of the present results that MUC1-C, E2F1, and PBRM1 regulate redox balance in PC cells, these findings indicate that the MUC1-C→E2F1→PBAF/PBRM1 pathway plays a role in protecting PC CSCs from ROS-induced genomic damage. Here, MUC1 is linked to pachyonychia congenita.