We identified a total of 288 unique promoters targeted by SIRT1 and CUL4B, which were then classified into various cellular signaling pathways using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway software (Fig. 3D), including Rap1, AMPK, FoxO, Hippo, cell cycle, focal adhesion, and regulating pluripotency of stem cells that are critically involved in tumor initiation and progression. This evidence concerns the gene SIRT1 and neoplasm.