qChIP analysis showed that SIRT1 and CUL4B strong enrichment on the promoters of selected genes involved in classical pathways, including FOXO3, GRHL3, NAV3, AF6, PRDM2, MOB1A, DLG1, CTNNA1, and CTNNA3, all implicated in tumor suppression (Fig. 3E). This evidence concerns the gene GRHL3 and neoplasm.