B12 prevents and reverses the development of diabetic cardiomyopathy in the ELMO1 hypermorphic Akita mice, at least via direct scavenging of superoxide and the retrieval of IGF-1 signaling via modulating the SAMe-DNMT-SOCS1/3 cascade (Fig. 8). Here, DNMT1 is linked to diabetic cardiomyopathy.