As both SOCS1 and SOCS3 bind to Janus kinase (JAK) 233 and inhibit intracellular signaling of GH receptors, our findings suggest that DNA methylation in the SOCS1/3 promoters enhanced by B12 supplementation leads to restored production of IGF-1 and contributes to ROS-independent beneficial effects of B12 on diabetic cardiomyopathy. The gene discussed is SOCS3; the disease is diabetic cardiomyopathy.