To what extent the high expression of ELMO1 contributes to the B12 effects we observed is currently unknown, yet we observed a similar cardioprotective effect of B12 even in the Elmo1+/+Ins2Akita/+ mice having normal expression of ELMO1 and less severe cardiomyopathy than Elmo1H/HIns2Akita/+ mice. Here, ELMO1 is linked to cardiomyopathy.