Here we showed that protein levels of TIMP-1, OPN, YKL-40, and active form of TGF-β1 in astrocytoma patient serum substantially differed as compared to control (healthy) group, while the differences between healthy control and meningioma group were observed only for ANGPT-1 and TGF-β1 active. The gene discussed is CHI3L1; the disease is meningioma.