We constructed decision tree classification algorithm for the indication of presence of astrocytoma—specific serum protein profiles, and found that tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), active transforming growth factor beta 1 (TGF-β1), C-X-C motif chemokine ligand 10 also known as interferon gamma-induced protein 10 (IP-10), angiopoietin-1 (ANGPT-1) and osteopontin (OPN) can be potential mediators of astrocytoma progression. The gene discussed is CXCL10; the disease is astrocytoma (excluding glioblastoma).