USO1 and acute lymphoblastic leukemia: We found a highly significant overlap between genes that were positively correlated with USO1 across the B-ALL samples and downregulated in USO1-depleted cells (Hypergeometric test; p < 0.0001), but not in genes that were upregulated in USO1-depleted cells (non-significant p value) (Fig. 4F, Supplementary 5C & 5D).