Of these, seven eGenes, namely LIPC, CFHR1, CFHR4, CFHR3, PILRA, PILRB, and TSPAN10 were previously reported to be regulated by single AMD-associated variants7 while 19 eGenes represent exciting new candidates becoming evident only due to additive effects of AMD-associated genetic variant combinations. The gene discussed is LIPC; the disease is age-related macular degeneration.