ROCK1 and heart failure: Trip10 (thyroid hormone receptor interactor 10, log2FC: − 0.73) was significantly downregulated in MyHC-mutant mouse hearts; Rock1 (log2FC: 0.12) implicated in perivascular fibrosis, transition from hypertrophy to heart failure, and Slc25a4 (adenine nucleotide transporter, log2FC: − 0.13) were significantly downregulated in TnT-mutant mouse hearts (Fig. 7a,b,d, Supplemental Table 5).