Using differential gene expression of G4-controlled genes as a parameter to identify cell-specific pathways, HaCaT cells displayed enrichment in genes involved in fibroblast growth factor receptors, typical of self-sufficiency in growth factor; cytochrome P450 related genes, which are a group of enzymes involved in skin protection60–62; DNA strand elongation and VEGFR vascular permeability and telomere synthesis, typically considered cancer hallmarks63. This evidence concerns the gene KDR and cancer.