In contrast, upon infection with AD169ΔIE1, we observed a 6.3-, 3.5-, and 2.2-fold decrease in IFIT1, Mx1, and IFIT3 enrichment, respectively (Fig. 4b, right panel), which further supports the crucial role played by the IE1 protein in PAD-mediated citrullination during HCMV infection. This evidence concerns the gene PADI4 and cytomegalovirus infection.