PADI2 and coinfection: Consistently, HFFs infected with a recombinant HCMV strain lacking the IE1 protein (AD169ΔIE1) displayed much lower levels of PAD2 protein expression at 48 hpi compared to cells transduced with the wild-type control (AD169), an effect that was reversed by AdVIE1 co-infection (Fig. 1g)26.