Within the p53flox/flox;Rbflox/flox;p130flox/flox conditional triple knockout SCLC mouse model in which green fluorescent protein (GFP) is expressed from the endogenous Hes1 promoter27, GFPhigh cells corresponding to the Notchhigh, low NE phenotype were enriched in inflammatory, immune and antigen presentation pathways compared to GFPlow cells consisting of the NE phenotype (FDR = 0) (Supplementary Fig. 15E, F). This evidence concerns the gene HES1 and small cell lung carcinoma.