By IHC, even the micro-metastatic cancer colonies detected in routinely operated, visually unaffected HGSC post-chemotherapy omentectomy samples (n = 2) were tightly surrounded by accumulating COL1 and FN-rich ECM (Fig. 2g, h and Supplementary Fig. 4a, b), highlighting the development of fibrotic TME even in micro-metastasis. This evidence concerns the gene FN1 and cancer.