FN1 and neoplasm: COL1 and fibronectin 1 (FN1) immunohistochemistry (IHC) of control omentum (n = 3) and pre-chemotherapy HGSC (n = 9) tissues validated the substantial desmoplastic stromal reaction around tumor cells, where both primary tumor and solid omental metastasis had developed prominent ECM surrounding the malignant cells upon diagnosis (Fig. 1f–h and Supplementary Fig. 1c–f).