Interestingly, among the top upregulated genes in tumor-associated HSPCs, we noticed genes coding for proteins that were previously shown to impact on hematopoietic stem cell maintenance and cell cycle progression (e.g., HMGB1, SOX4 and STMN1, in both HSCs and MPPs50–52) or to mediate tumor progression such as TMSB1053. The gene discussed is SOX4; the disease is neoplasm.