TNF and glioblastoma: Interestingly, HSChigh glioblastoma samples significantly associated as well with increased expression levels of TGFB1 and IL10, two genes coding for classical immunosuppressive cytokines (p = 1.4 × 10−7, and p = 9.7 × 10−12 respectively, Student’s t-test), but not with expression of proinflammatory cytokine genes such as IL2, IFNG, IL12 or IL17. An exception to this were TNF and IL662,70, which positively associated with the HSChigh samples (Fig. 6f and Supplementary Fig. 11a).