Moreover, HSChigh glioblastoma samples also exhibited significantly higher expression of chemokines such as IL8, CCL2 and CCL4, in agreement with our organoid co-culture experiments shown in Fig. 5j (Supplementary Fig. 11b) or niche factors such as CXCL12, LEPR (leptin receptor), and FN1 (fibronectin) (Fig. 6h)32. This evidence concerns the gene LEPR and glioblastoma.