HSPC-conditioned media promoted migration of AHNPs in vitro and co-cultures with patient-derived glioblastoma cells induced the secretion of tumor-promoting cytokines such as IL-6 and IL-8 or the immunosuppressive-related chemokine CCL2, indicating a potential role of HSPCs in promoting both, immunosuppression and malignancy phenotypes during glioblastoma progression. Here, CCL2 is linked to glioblastoma.