However, the glioblastoma microenvironment is characteristically immunosuppressive compared to other malignancies, owing to, at least in part, potent immunosuppressive cytokines such as TGF-β and IL-105, negative regulators of effector cell functions such as programmed death-ligand 1 (PD-L1), indoleamine 2,3-dioxygenase (IDO) and oncometabolites such as (R)-2-hydroxyglutarate6,7. The gene discussed is CD274; the disease is glioblastoma.