Moreover, HSChigh glioblastoma samples also exhibited significantly higher expression of chemokines such as IL8, CCL2 and CCL4, in agreement with our organoid co-culture experiments shown in Fig. 5j (Supplementary Fig. 11b) or niche factors such as CXCL12, LEPR (leptin receptor), and FN1 (fibronectin) (Fig. 6h)32. Here, CXCL12 is linked to glioblastoma.